Alpha-GPC (Alpha-glycerophosphocholine or sometimes just glycerophosphocholine) is a natural compound found in certain foods like milk. It contains a substance called choline, which, when ingested, turns into a powerful neurotransmitter called acetylcholine. Acetylcholine is involved in both cognitive functions like learning, attention span, and memory, as well as muscular contractions.
Animal research has shown that supplementation with alpha-GPC increases acetylcholine levels in the brain, and human research has shown that it improves cognitive function in people with Alzheimer’s.
Research has also found that supplementation with alpha-GPC can increase growth hormone production as well as peak force production (strength) while working out.
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The standard dosage of alpha-GPC is 300-600 mg per day. The studies that showed increase growth hormone production and peak force production used 1 gram and 600 mg, respectively. 600 mg per day is commonly accepted as a good dose for athletes.
For the reduction of symptoms of cognitive decline, the dosages are commonly higher. Almost all studies use 1.2 grams per day, divided into 3, 400-mg doses.